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Even extreme poverty, physical illness, or personal tragedies do not necessarily lead to schizophrenia unless they have psychological ramifications that hurt the sense of self.

Personality disorders have also been a focus, particularly borderline personality disorder.

Extreme versions of trauma models have implicated the fetal environment and the trauma of being born, or have been associated with recovered memory controversies.

The trauma model of mental disorders, or trauma model of psychopathology, emphasizes the effects of psychological trauma, particularly in early development, as the key causal factor in the development of some or many psychiatric disorders, or a vulnerability for depression and anxiety, in addition to trauma as an adult as in post-traumatic stress disorder.